
Ticks are icky. They spread Lyme disease. And now it appears they might interfere with your ability to enjoy a hamburger. A team headed by Dr. Thomas Platts-Mills, UVA professor and former president of the American Academy of Allergy, Asthma and Immunology, recently published findings that suggest that tick bites may cause allergic reactions to red meat. Dr. Platts-Mills says that tick saliva may trigger the human immune system to produce antibodies to a carbohydrate called alpha-gal, which is found in red meat.
Dr. Scott Commins, an assistant professor of medicine at UVA and lead author of the study, explains that an allergic reaction occurs when the body produces antibodies—meant to defend against harmful bacteria or toxins—against an otherwise benign substance, the allergen. When antibodies bind to the allergen, certain cells release histamine, which in turn causes symptoms such as swelling, hives and breathing problems.
The researchers screened hundreds of human blood samples from locations in the U.S., Africa and Central America for the antibodies against alpha-gal. Their findings? Meat allergies are more common in places where tick populations are on the rise. The team also studied people with the allergy in the laboratory setting. “We’re sure ticks can do this,” Dr. Platts-Mills told the Washington Post. “We’re not sure they’re the only cause.”
Unique to this particular allergy is that the reactions are delayed. Symptoms don’t appear until several hours after exposure, which can make them difficult to diagnose. “We have now performed this under observation, and there are no symptoms until after 3 to 4 hours,” said Dr. Commins. Dr. Platts-Mills and his colleagues’ next topics of study: Why are the allergic reactions so delayed? And why do only some people develop the problem?
Comments
Heather Drinkwater on 01/21/2019
I and four of my children tested positive for alpha gal to varying degrees, with one son and I, who also have Lyme, testing the highest. We all react to different degrees. Fortunately, no anaphylaxis, though before my text came back, I had steak nachos with my 21 year old on his birthday and sound up with HUGE lips and a swollen face, so I am being careful. I’ve found items with gelatin, such as gummy bears, affect me, too. Sigh. I miss burgers. Turkey burgers aren’t the same. We recently discovered something completely plant based called The Impossible Burger. It is only sold in restaurants right now, but It was amazing. Two of my children tested with less of a reaction after 18 months of a limited diet, so perhaps for them, there is hope. I am not counting on it, as my score topped the charts, but I keep looking for advancements for the kid’s sakes.
Heather Drinkwater on 01/21/2019
I and four of my children tested positive for alpha gal to varying degrees, with one son and I, who also have Lyme, testing the highest. We all react to different degrees. Fortunately, no anaphylaxis, though before my text came back, I had steak nachos with my 21 year old on his birthday and sound up with HUGE lips and a swollen face, so I am being careful. I’ve found items with gelatin, such as gummy bears, affect me, too. Sigh. I miss burgers. Turkey burgers aren’t the same. We recently discovered something completely plant based called The Impossible Burger. It is only sold in restaurants right now, but It was amazing. Two of my children tested with less of a reaction after 18 months of a limited diet, so perhaps for them, there is hope. I am not counting on it, as my score topped the charts, but I keep looking for advancements for the kid’s sakes.
Rita Schaefer on 01/10/2018
5 yrs ago I went to the E.R. at midnight with a rash covering my whole body. I was going into shock. E.R didn’t give my any answers because I had no known allergies or medical problems. 6 months later it happened again. An allergist tested my blood and said it was the lone star tick disease. My question is :. Is there a cure? Last year I was down to a 1.63 and this yr it is a 2.69. I have done everything possible to fight this. My doctor said I’ll just have to live with it. He says dairy products shouldn’t bother me. I don’t agree. I don’t eat gelatin products or dairy.
Marilyn on 10/10/2017
@Donna Saad..I have been questioning that as well but seems most people have different blood types. I am O+ :( My BF is A+
Donna Saad on 10/10/2017
Wondering if anyone has studied if certain blood types more susceptible to Hashimotos and or Alpha Gal allergy. I am type A.
Marilyn H on 10/09/2017
I have had Hashimotos (Hypothyroid) for about 30 years. I was just diagnosed last week with Alpha-Gal allergy. Maybe a connection between the two? I was bitten by quite a few lone star ticks and so was my boyfriend, but he is not positive for the AG and I am? Trying to figure out a correlation?
Jean Jerread on 05/28/2017
Fo 10 months I suffered with a rash that looked like mosquito bites all over my whole body. Primary docs, allergists and dermatologist didn’t have a clue what was going on, even after ointments, creams and all kinds of pills for itching. Finally my primary doctor’s nurse called me one evening and said that she had been researching my condition and wanted me to see an immunologist in Easton, Maryland. I made an appointment right away and he had me do a long list of lab work which indicated no food allergies but that I did have a high positive for the Alpha Gal IgE antibodies. Which means no red meats. I live just 13 miles East of Ocean City, Md. Today I pulled a lone star tick from my little Yorkie Poo? Will he suffer the same issues as a human?
Wendy Banks on 12/23/2016
My son started having reactions summer of 2013. He was 13. After going to an allergist and leaving crying with no answers except my son must be lactose intolerant. He would not listen. A friend mentioned Alpha Gal to me. I googled it and oh my!!! This was it!!! 2 1/2 years later we found an allergist who is familiar with Alpha Gal. He has now been tested. Waiting on results. Certain his levels will be high. But very thankful to have someone who don’t think we are crazy.
My son cannot have milk, or milk products and of course any kind mammal meat or products.
Good luck and God Bless to all.
Merry Christmas
#nomammal meat
#nomilk
#eatathome
Stephanie B. on 12/19/2016
MD, one last thought! Reading labels is a fantastic way to be on the lookout for those ingredients your son needs to stay away form. Learn the different names of the ingredients you know he is allergic to, for example; milk, under other names like whey, lactose, casein (non-dairy products may still contain casein that’s why I look for the product to show Vegan on the label), cream, etc. Here’s a site to help get you started on the milk products to avoid. Just copy and paste this link into your browser and be amazed at all the products that you thought were safe from dairy. http://www.kidswithfoodallergies.org/media/Milk-Allergy-Avoidance-List-Hidden-Names.pdf
Stephanie B. on 12/19/2016
Dear MD,
I’m so sorry to hear about your son, but at least now you know what he has and you can start to help him. All of this is overwhelming at first and the internet will become your new best friend for the next few weeks. It is a wealth of information and offers tons of info on Vegan recipes, products, and advise. Vegan means animal-free. I do a combination Vegan/carnivore diet. I eat chicken, fish, and turkey and modify our favorite recipes to fit Vegan recipes (dairy and egg free). I find that whatever I’m searching for online, I type in the word “VEGAN” in front of it and the web usually offers an array of sites to search from. Example: Vegan hotdogs, Vegan bread, Vegan shampoo, Vegan eggs, Vegan milk, Vegan butter, Vegan soft drinks, Vegan vegetables (yes, if your fruit or veggie is not certified organic then it was probably sprayed with a wax that may contain an animal by-product) I found a dish soap called Seventh Generation that is Vegan and I wash my lemons under cool water and a drop of that soap before I use them for fresh lemonade…Keep in mind that different web browsers offer different sites too! If you haven’t already you might take your son to an allergy dr. and have him tested for environmental and food allergies as well, that way you know everything you’ll need to eliminate from his environment and diet. I ate corn all my life and never had a problem with it (I thought) until I had my food allergy test and it showed I have an allergy. I eliminated it from our meals and other products that contain high fructose corn syrup, corn bread, hush-puppies, corn starch, catsup, etc. I snuck and had 2 tbs of whole kernel corn with a meal the other day and about 10 minutes later it felt like my head was going to explode. I had the worst headache and my chest became very tight and I was having some difficulty breathing. So, lesson learned! As for the overwhelming alpha-gal info and your boy, you might try simplifying your meals back to the basics. I buy all the plain fresh or frozen chicken, fish, and turkey I can get my hands on. If he can eat turkey, you can substitute ground turkey in all the dishes that call for ground beef. Plus, by getting allergy tested you will have a thorough list of allergens you can give to your pharmacist so they can cross-reference has allergies with the ingredients in his prescribed medications. I was the convenience foods queen and since my alpha-gal diagnosis, 2 months ago, I now have to cook every meal from scratch. No more deli meats, any foods with breading, no cheese (even cottage cheese), yogurt, no dairy, no store bought bakery goods, watch the pastas because of his egg allergy, the list goes on! I read someplace that it’s common for alpha-gal sufferers to suffer from celiac disease too. Celiac disease is a genetic autoimmune disorder where the ingestion of gluten leads to damage in the small intestine and leads to stomach pain, diarrhea, malabsorption of vitamins…all the things that sound horrible, but can be managed by tweaking a diet. I hope this helps. We are all in this together. Stay hopeful and stay well.
MD on 12/19/2016
My 7year old was just diagnosed with alpha gal and it has taken over a year to find out this is what was going on. All this is new and over whelming and I need suggestions he has the GI side effects. I have been reading the labels and cutting everything out and feel like l keep missing something because he still complains of stomach ache daily and head ache. He is allergic to all the red meats, dairy and eggs. I didn’t know about the laundry soaps I just read that in a comment, this is not common in our area and I have no help at getting information
Stephanie B. on 12/18/2016
Dear Kristy A,
I read your post and have been concerned. The prednisone may have played a contributing factor to your son’s deteriorating health. I found some info on Livestrong.com and Drugs.com that may be helpful. Prednisone contains ingredients that some alpha-gallers may not be able to tolerate. Some of the inactive ingredients in prednisone are lactose monohydrate, magnesium stearate, and pre-gelatinized starch. Lactose monohydrate is one of two forms of a natural sugar that is found in cow’s milk (lactose). Magnesium stearate (which is magnesium and stearic acid that is bound together). Stearic acid naturally occurs in grass-fed beef. Finally, pre-gelatinized starch is used as a thickener, plus it helps to keep pills from sticking together. All of the Vegan information I have read so far offers to steer clear of anything containing “gelatin”. Gelatin is made from animal by-products (it’s the bone marrow). However, starch is a plant-based thickener. But as always, rely on your pharmacist for the most up-to-date medication information. I found out the hard way. My breathing treatments contain ingredients that alpha-gallers cannot have. I did not know at the time, but I was having allergic reactions (trouble breathing) that I was mistaking for asthma. I was not getting any relief from my rescue inhaler. Benadryl and Pepcid are what works for my allergic reactions.
Stephanie B. on 12/18/2016
Hello All,
I just wanted to do an FYI: on some new or (new to me) information that I found on the alpha-gal.org/basics website under the Awareness Links under the Pharmacy Times Article. I found this article to offer an update, as of May 27,2015, on a newfound place where the alpha-gal epitope hides. If you have been diagnosed with alpha-gal and have eliminated everything in your life that has to do with mammalian products, but still suffer, this article offers new information. Researchers at the University of Virginia have found the alpha-gal epitope in cat dander. All sufferers have different levels of toleration for alpha-gal, some worse than others. I cannot tolerate ANYTHING mammalian, but have a neighbor with alpha-gal that has only needed to eliminate beef and pork. However, they can drink cow’s milk and eat cheeses made from cow’s milk and they do just fine. I hope this is helpful. On a lighter note, get creative with modifying your favorite holiday treats (de-alpha-galling them) and have yourself a wonderfully blessed and healthy holiday.
Loraine Stubblefield on 12/16/2016
To donna saad, i was just diagnosed with alpha-gal and have had hashimotos since 1979.
Stephanie Byerly on 11/30/2016
I was recently diagnosed with alpha-gal by an allergy doctor. I also have hypothyroidism, hormone imbalances, and a multitude of other foods, plus environmental allergies. I have my medications filled at a compound pharmacy and ask that all my medications be vegetarian (egg free) or vegan. I was diagnosed with asthma and found that my rescue inhaler was not working as well as before. This was because I was still exposed to allergens (in my diet, soaps, snacks, ect). My advise is, research your products. Know what’s in them before you buy them and when in doubt, do without. There are thousands of products that contain animal by-products so stay on-line and read, watch videos, articles…everything you can get your hands on. There is little known about this but researchers are working hard to gather more information. Doctors have little or no knowledge of alpah-gal so you have to be your own advocate! You must avoid any animal that has a hoof; pig, cow, goat, beef, bison, deer. Know what “mammals” animals are. Avoid cows milk, whey, cheese, cottage cheese and cream cheese, gelatin (learn the different names of the animal products) Also, medications have animal by-products in them so YOU make sure to ask the pharmacist if your medicines can be made vegetarian or vegan. Your doctor will write the prescription but it is up to you to make sure and ask the pharmacist if it contains animal. Communicate with your doctor and insist on an alpha-gal screen (blood work) if you think you may have this condition. Anything that you wear, smear on your body, or ingest most likely has animal-by-products in it. Even the wax spray that’s on our fruits and vegetables most likely contain animal or filtered through filters made from animal. So, keep your meals simple. If you can tolerate eating turkey, fish, and chicken do so and shop the outer perimeter of the grocery store for fresh fruits and veggies and make sure to read the labels even if it is a fruit or veggie. If it has a label, read it! Do your homework before going to the store. Be careful when dining out because they butter everything (cow butter comes from cow’s milk). Buy vegan cookbooks and learn how to prepare foods. Research the different brands of laundry “vegan” detergents, soaps, shampoos, lotions, toothpastes, deodorants and all natural household cleaners. According to a University Of VA study, 3 out of 300 people have the ability of reversing this so stay optimistic and don’t give up hope. Hope this makes sense, I was in a hurry when I typed it. Stay well!
Kristy Arnold on 11/28/2016
My 12 year old son has alpha gal syndrome. 2 weeks ago he began to have tremors or jerks of his entire body 11 hours after taking 30 mg of prednisone and a breathing treatment. Now it is effecting his speech. The only time his body is still is when he is asleep. No one has been able to tell me why or how to stop them. We have been in 3 different pediatric hospitals, several neurologist teams and have had MRI, CT, EEG, blood work, urine test etc…. All normal. Anyone have any ideas?
Heather on 11/05/2016
I have hypothyroidism 25 yrs. and alpha gal for 5 months.
Tammy Campbell on 10/17/2016
I have alpha gal severely. Took 7 years to figure out. I just recently started using Premarin cream and I know that come from horses and have allergy symptoms. Is this possible? I got off it for awhile then used again last night and I’ve had a tingling sensation(almost burning sensation) all day.
joy wolf on 10/01/2016
I have hashimotos and the alpha gal allergy.
Melissa on 08/24/2016
Is the alpha-gal supplement in animal feed the same type of thing that the tick saliva has? Could this supplement harm people?
Catherine M McPeters on 08/02/2016
Helpful? to add eyesight gets scary- very sudden blurry vision to extreme…allergy to all Rx , need advice on teeth and eye cateract surg needed, Dr Harmon office suggest I try UVA…afraid they may make it woarse with Antibiotics:
Catherine M. McPeters on 08/02/2016
Hypothyroid Problem? Rx for years…..noted with alpha-gal, does the rx contain any mammalian? noted various symptoms of tiredness and less able to relax….memory terrible and unable to eat anything other than vegan , since diag. positive
Donna Saad on 05/22/2016
Anyone have Hashimotos thyroiditis in addition to alpha-ga?